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KMID : 0606319940100010017
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Journal of Phamacetical Sciences Sookmyung Women s University
1994 Volume.10 No. 1 p.17 ~ p.24
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Pharmacological studies on tetrachloro-[bis(2-chloroethyl) ethylenediamine-N, N'] platinum(IV)
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박은희
임경화/신윤진/박미화
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Abstract
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Abstract:
@EN The platinum complex, PtCl4(2-Ceen), was previously synthesized and shown to have anti-tumor activity. In the present study, toxicologic profile of PtCl4(2-Ceen) and its acute anti-inflammatory activity on carrageenin edema was observed with
oral
administration. The effect of this agent on acetic acid-induced writhing in mice were also examined. In male and female mice given a single intragastrical done of PtC14(2-Ceen), we determined that LD50 values were over 1000mg/kg B.W. In the
method
of
carrageenin edema and writhing test, the PtCl4(2-Ceen) orally administered in a single dose, tended to inhibit the development of hind paw edema in rats, and the number of writhing induced by acetic acid in mice. These facts suggest that
PtCl4(2-Ceen)
may have weak anti-inflammatory effect.
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KEYWORD
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